P261 Burden of bowel urgency across specific treatment groups among Ulcerative Colitis patients – real world global study analyses

Abstract Background Bowel urgency, the sudden and immediate need to have a bowel movement, is common symptom in ulcerative colitis (UC) associated with higher disease activity, decreased work productivity markedly reduced quality of life1. This study explored differences burden among UC patients urgency based on their treatment pathway. Methods Data were extracted from Adelphi Disease Specific Programme for UC, point-in-time survey gastroenterologists (GIs) Jan 2020-Mar 2021 Germany, France, Spain, Italy, UK US. GIs provided patient demographics, clinical characteristics history. The same invited complete Short Inflammatory Questionnaire (SIBDQ), EQ-5D Work Productivity Activity Impairment (WPAI) questionnaire. Three subgroups identified: never received targeted therapy (biologics JAK inhibitors) (TT-naïve), receiving first TT currently (1L TT) prior use (TT-exp). Within these groups, experiencing day- or nighttime reported by physicians, current duration >3 months, included. ANOVA, chi-squared Kruskal-Wallis tests used compare groups. Results Of TT-naïve (n=595), 1L (n=851) TT-exp (n=321) 23%, 17% 26% experienced respectively. those younger lower BMI lowest proportion smokers vs. groups (Table 1). 70–80% across three remained non-remission derived Mayo score, while 19% group flaring 18% 32% (p=0.0324). Steroid was highest (43%) 10% (p<0.0001). had number visits healthcare professionals last 12 months. outcome measures indicated substantial similar life impairment all 2). only significant difference working (31% TT-naïve, TT, 28% TT-exp; p=0.0232). Conclusion confirmed that still experience despite treatment. Since known negatively impact patients’ life, there therapeutic address this symptom. Reference 1. Ha, C, et al. Rectal Urgency Among Ulcerative Colitis Crohn’s Patients: Analyses Global Survey. Poster presented at: Digestive Week; May 21–23; Online event.